Duke met his wife, Laurie, who also has NF in an online chat room for people with neurofibromatosis back in June 2002. Duke was living in Kentucky and Laurie was living in Virginia. After a couple of months of online chatting they met face to face in Tennessee later that summer in August. They were engaged November 2002 and married in Kentucky in July 2003. They decided it was best for Duke to move to Virginia so Laurie could continue to see her NF specialists who keep her as healthy as possible. They do not have children but they share an apartment with their two cats.